There are lots of things to like about The Oatmeal--it's clever, it's generally easy to relate to, and it so often says what I'm thinking about a million times better than I could.
This is why a friend and I went to a book signing several days ago to see Matthew Inman (the founder of the webcomic who referred to himself, I believe, as "Mr. Oatmeal"). He was promoting his book, 5 Very Good Reasons to Punch a Dolphin in the Mouth (and Other Useful Guides) although he didn't actually sell too many copies that night.
I was a little curious as to how a reading of a comic book would go. There was apparently supposed to be a projector present, but Mr. Oatmeal did well enough without it, instead explaining how The Oatmeal came into existence, how he chooses the topics to write about, and how he has chosen the particular style of drawing for which the comics are known.
Also notable was his enthusiasm for the internet as a medium for accomplishment--he is a one-man show who has managed to rocket to national attention, making money not from annoying ads on his site but from merchandise sales. He now has a book on sale for less than $8. This is a man who knows the power of the people.
In order to make this somewhat relevant to a "literary" blog, I'll link here to some of The Oatmeal comics that have been somewhat "literary" in nature and let you fools poke around his site for yourselves if you haven't already:
The 3 Most Common Uses of Irony
How to Use a Semicolon