Basically, if you like The Oatmeal, you'll like this book. It includes a number of the webcomics in expanded form and "25+ never before seen comics."
If I had to sum up the book in one word, it would be: "awesome." If I had to sum it up in two words, they would be: "totally awesome."
Seriously. I just sat in a coffeeshop by myself for forty-five minutes and giggled. Totally awesome. Check it out.